Improved metagenomic analysis with Kraken 2

Other free copies

• Cold Spring Harbor Laboratory (biorxiv.org)Accepted manuscript · PDF
• National Institutes of Health (ncbi.nlm.nih.gov)Preprint · Web page

Abstract

Although Kraken's k-mer-based approach provides a fast taxonomic classification of metagenomic sequence data, its large memory requirements can be limiting for some applications. Kraken 2 improves upon Kraken 1 by reducing memory usage by 85%, allowing greater amounts of reference genomic data to be used, while maintaining high accuracy and increasing speed fivefold. Kraken 2 also introduces a translated search mode, providing increased sensitivity in viral metagenomics analysis.