ColabFold: making protein folding accessible to all

Other free copies

• Cold Spring Harbor Laboratory (biorxiv.org)Accepted manuscript · PDF
• researchsquare.comAccepted manuscript · PDF
• National Institutes of Health (ncbi.nlm.nih.gov)Preprint · Web page
• Asklepios Klinik St. Georg (resolver.sub.uni-goettingen.de)Preprint · Web page

Abstract

ColabFold offers accelerated prediction of protein structures and complexes by combining the fast homology search of MMseqs2 with AlphaFold2 or RoseTTAFold. ColabFold's 40-60-fold faster search and optimized model utilization enables prediction of close to 1,000 structures per day on a server with one graphics processing unit. Coupled with Google Colaboratory, ColabFold becomes a free and accessible platform for protein folding. ColabFold is open-source software available at https://github.com/sokrypton/ColabFold and its novel environmental databases are available at https://colabfold.mmseqs.com .