Sensitive protein alignments at tree-of-life scale using DIAMOND

Other free copies

• University of Dundee (discovery.dundee.ac.uk)Accepted manuscript · PDF
• National Institutes of Health (ncbi.nlm.nih.gov)Preprint · Web page

Abstract

We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP.